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Sixty elderly men were put on various Ostarine dosages for 3 months, and it was found that simply taking 3mg of Ostarine per day led to an increase in muscle mass by 1.76kg . Further work showed that taking Ostarine (3mg/day) for 4 months improved the level of skeletal muscle in the elderly men with osteoporosis . However, it is important to note that these findings are not based on a controlled study and therefore, more work should be done to further investigate the benefits of Ostarine supplementation in the elderly. The use of Ostarine and a combination vitamin/mineral diet in the elderly may be particularly beneficial for those with osteoporosis, but it is not known whether using this same combination regimen in other populations should also be considered. Oxygen-restricted diets Oxidative stress is one of the most important causes of degenerative diseases, but the exact mechanism in which oxygen deprivation reduces lifespan has been controversial . Ostarine has been claimed to reduce the formation of reactive oxygen species, a process that can lead to cellular death . Ostarine also plays a protective role for mitochondria . In addition, Ostarine has been linked to a reduction in the production of reactive oxygen species . In a study on mice, Oxygen deprivation (oxygen saturation <30%) was associated with a decline in protein synthesis in the skeletal muscle of aged mice, suggesting that oxygen deprivation can increase protein degradation due to an increased production of reactive oxygen species . In humans, Ostarine supplementation increased the rate of protein synthesis and reduced the rate of protein breakdown in older adults . However, another study showed that a daily oral dose of 10mg/kg Ostarine (in this case in the form of Ostarine-A) did not improve exercise capacity or functional status of older aged subjects . These results suggest that there is no reason to be concerned that Oxidative stress is a necessary determinant of increased susceptibility to age-related diseases in humans. However, it is well known that exercise capacity is strongly dependent in part on blood nitric oxide levels, which have been shown to be elevated at rest and in stressful situations . A study of older women found a modest increase in blood nitric oxide levels (in the range of 30-45% of baseline) when taken after an exercise test for 2 days, followed by 40mg/day of Oxygen-Restricted Diet (ORD), although overall no significant improvement in exercise capacity was found in the ORD group, which may have been due to a short time period between testing and initiation of the ORD Related Article: